BTLA Antikörper (APC)

Produktnummer ABIN7672816

Dieses Anti-BTLA-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von BTLA in FACS. Geeignet für Maus.

Kurzübersicht für BTLA Antikörper (APC) (ABIN7672816)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser BTLA Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: PK18-6

Produktdetails anti-BTLA Antikörper (APC)

Verwendungszweck: APC Anti-Mouse CD272/BTLA Antibody

Aufreinigung: 0

Reinheit: 0

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Andere Bezeichnung: CD272

Hintergrund:

Synonyms: B- and T-lymphocyte attenuator|B- and T-lymphocyte-associated protein|Btla|CD272

Background: CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

Molekulargewicht: 0

Gen-ID: 208154

UniProt: Q7TSA3

Pathways: Cancer Immune Checkpoints